Haemodialysis-related fatigue
Research type
Research Study
Full title
Haemodialysis-related fatigue and its association with electroencephalographic and electromyographic changes
IRAS ID
218292
Contact name
Raja Mohammed Kaja Kamal
Contact email
Sponsor organisation
East and North Herts NHS Trust
Duration of Study in the UK
0 years, 6 months, 1 days
Research summary
Extreme fatigue after haemodialysis is a very common but poorly understood problem. The underlying cause of dialysis-related fatigue is unclear and there are no specific treatments for dialysis-related fatigue. The purpose of this research is to investigate the acute effect of haemodialysis on brain wave activitiy and muscular activity using electroencephalogram (EEG) and electromyography (EMG). Comparison of EEG and EMG activity will be made between patients with extremely prolonged fatigue times (recovery time >12 hours) after dialysis and those with short fatigue times (recovery time <2 hours). EEG and EMG analysis will be carried out on patients before and after their dialysis treatments on a single day and results will also be compared before and after dialysis.
Patients will be asked to complete the the Chalder Fatigue questionnaire, which has been validated in the haemodialysis population. Correlation between component of the questionnaire and EMG/EEG parameters will be studied. Dialysis and haemodynamic parameters such as blood pressure, amount of fluid removed during dialysis (ultrafiltration) will be collected on the day of the study to see if this is associated with fatigue scores, EEG and EMG parameters.
This will be an inital pilot study since EEG/EMG studies in relation to dialysis-related fatigue has not been done before. Depending on the findings, the study may be expanded to include more participants.
REC name
London - West London & GTAC Research Ethics Committee
REC reference
16/LO/2229
Date of REC Opinion
19 Jan 2017
REC opinion
Further Information Favourable Opinion