HAAPI
Research type
Research Study
Full title
High flow with Automatic Apnoeic oxygenation for Preterm Intubations- Randomised control trial (HAAPI)
IRAS ID
358508
Contact name
Vrinda Nair
Contact email
Sponsor organisation
South Tees NHS Foundation Trust
ISRCTN Number
ISRCTN40770512
Duration of Study in the UK
1 years, 5 months, 31 days
Research summary
Some premature babies need placement of a breathing tube in the airway as a lifesaving procedure. This procedure is called intubation and one of the most difficult procedures to perform especially in a small premature baby. Intubation in neonates has a low success rate, as most often the procedure has to be stopped and then retried. One of the main reasons to stop the procedure is that a baby’s oxygen and heart rate goes low during the procedure. Providing breathing support using nose prongs (called high flow) along with automatic control of oxygen could better support the babies during the procedure and prevent low levels of oxygen. However, we do not know whether providing breathing support using “high flow” along with automatic control of oxygen is better than only providing breathing support using “high flow” and manual adjustment of the amount of oxygen. With the proposed study, we would like to compare providing breathing support using the “high flow” with manually adjusted oxygen as compared to providing breathing support using “high flow” along with automatic control of oxygen in babies undergoing intubation procedure to study which method prevents low oxygen levels most effectively.
REC name
North of Scotland Research Ethics Committee 1
REC reference
25/NS/0055
Date of REC Opinion
30 May 2025
REC opinion
Favourable Opinion