H. pylori and gastric secretory function
Research type
Research Study
Full title
H. PYLORI INFECTION AND ACID SECRETORY FUNCTION OF ENTIRE GASTRIC MUCOSA AND IN PARTICULAR OF MUCOSA CLOSE TO THE GASTROESOPHAGEAL JUNCTION IN HEALTHY VOLUNTEERS
IRAS ID
155379
Contact name
Kenneth E.L. McColl
Contact email
Sponsor organisation
NHS Greater Glasgow and Clyde
Research summary
The incidence of a form of cancers affecting the lower gullet called oesophageal denocarcinoma has risen by 3-4 fold over the past thirty years in the Western world. The recognised environmental risk factors (obesity and smoking) explain less than 10% of this increase. About 50% of the general population have a bacterium living in their stomcah called Helicobacter pylori (H. pylori) and they are three times less likely to develop oesophageal adenocarcinoma than similar people without this infection. If the infection protects against the cancer then the recent rise in the cancer could be explained by the recent fall in this infection. The infection can reduce stomach acid secretion, though there is very little information on this effect in the general population and no information on this effect on the stomach lining closest to the gullet which is recognised to be most important in inducing oesophageal adenocarcinoma. H. pylori suppression of acid secretion by the stomach lining close to the GO junction would provide a plausible mechanism for the rising incidence of oesophageal adenocarcinoma. We propose to investigate acid secretion by the total stomach and, in particular, of the stomach close to the gullet in H. pylori-infected and uninfected healthy volunteers.
REC name
West of Scotland REC 3
REC reference
14/WS/1026
Date of REC Opinion
4 Jul 2014
REC opinion
Further Information Favourable Opinion