Gyros

• Research type

  Research Study

• Full title

  Gyrate Atrophy Ocular and Systemic Study

• IRAS ID

  342005

• Contact name

  Michel Michaelides

• Contact email

  michel.michaelides@nhs.net

• Sponsor organisation

  Jaeb Centre for Health Research

• Clinicaltrials.gov Identifier

  NCT05312736

• Duration of Study in the UK

  4 years, 9 months, 18 days

• Research summary

  The Gyrate Atrophy Ocular and Systemic Study characterizes the natural history of ornithine levels and retinal degeneration (RD) associated with disease-causing OAT variants in the presence of standard care dietary treatment regimens over 4 years. The research goal is to understand the impact of OAT mutations on plasma ornithine levels and retinal degeneration. The target population for GYROS will be patients with gyrate atrophy associated with disease-causing variants in the OAT gene.

• REC name

  Wales REC 5

• REC reference

  24/WA/0325

• Date of REC Opinion

  25 Nov 2024

• REC opinion

  Further Information Favourable Opinion