GYPSIE - Glycoprotein Six in Stroke

• Research type

  Research Study

• Full title

  Genes and Platelets in Stroke - Glycoprotein Six in Stroke (The GYPSIE study)

• IRAS ID

  154364

• Contact name

  Stephanie Jung

• Contact email

  smj52@cam.ac.uk

• Sponsor organisation

  Cambridge University Hospitals NHS Foundation Trust & University of Cambridge

• Research summary

  This study aims to investigate genetic predisposition for stroke. Patients presenting at A&E with stroke will be invited. The study will involve blood sampling upon admission to hospital and a second sample will be taken at the clinical follow up, approximately 90 days later.

  Various genetic and biochemical measurements will be performed using the collected blood sample, including sequencing of genetic material such as DNA and RNA. Analysis results will be compared to controls recruited under separate ethics (Genetic analysis of platelets in healthy individuals, REC reference 10/H0304/65)

  We will be recruiting :
  - Patient index cases with stroke as they present at Cambridge University Hospital A&E with stroke (300 patients)
  - Relatives of patients (up to 100 individuals)

  The enrolment will be done by the stroke team at Cambridge University Hospital A&E

  We will collect Biological Materials for use in research that aims:
  1) To investigate the genetic basis of stroke
  2) To investigate biomarkers in the blood and their connection to stroke
  3) To unravel the molecular mechanism by which the DNA variants affect platelet function, and more generally result in stroke

  The potential benefits of the research for the NHS and the wider public are:
  - Improved diagnosis (within 5 years) for cases with stroke
  - Possible identification of new drug targets for patients with stroke.
  -Better classification of stroke into subgroups benefiting from different treatments.

  The research data generated by the study will be stored for at least 10 years. Biological Materials will be stored as long as funding is available. In case of lack of funding, materials will be transferred to a biorepository, or materials may be destroyed. DNA and RNA sequence data will be deposited in databases such as the EGA for use in other ethically approved research.
  

• REC name

  East of England - Essex Research Ethics Committee

• REC reference

  14/EE/1062

• Date of REC Opinion

  6 Oct 2014

• REC opinion

  Further Information Favourable Opinion