Guillian-Barre Syndrome: electro-clinical patterns
Research type
Research Study
Full title
Guillian-Barre Syndrome: antecedent infections, electro-clinical patterns and outcomes
IRAS ID
186780
Contact name
David Allen
Contact email
Sponsor organisation
R&D Department, University Hospital Southampton NHS Foundation Trust
Duration of Study in the UK
0 years, 8 months, 4 days
Research summary
This study will address a relatively rare condition called Guillain-Barre Syndrome, which is caused by the patient's own immune system attacking their bodies nerves. It causes sensory symptoms and weakness to varying degrees, from mild to severe. A few different forms occur. The trigger for the immune system attack often appears to be an infection, that precedes onset. Why particular forms occur is not clear. It may be related to what the preceding infectious cause is. This project will retrospectively review the clinical history, laboratory findings, clinical examination findings and detailed neurophysiologcial (nerve conduction tests) findings in cases seen at the institution, to assess whether there are any particular forms, that can be associated with particular infective causes. This may also influence the outcome and severity of the disease.
Nerve conduction tests are a safe and harmeless method by which the communication along nerves in the body can be assessed externally, using small electrical impulses and a sensitive computer.REC name
London - South East Research Ethics Committee
REC reference
15/LO/1758
Date of REC Opinion
8 Oct 2015
REC opinion
Favourable Opinion