Guiding Balloon Dilatation of Lung Artery Blockages From RV Function
Research type
Research Study
Full title
Use of right ventricular conductance catheter guidance to optimise balloon pulmonary angioplasty as a non surgical treatment of chronic thromboembolic pulmonary hypertension.
IRAS ID
229599
Contact name
Stephen Hoole
Contact email
Sponsor organisation
Royal Papworth Hospital NHS Foundation Trust R and D
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
Blockages in lung blood vessels can be treated by stretching them open with a balloon.This new therapy is called Balloon Pulmonary Angioplasty (BPA). It clears obstructions and improves blood flow to the lungs with beneficial effects on the right side of the heart. When blockages are present this puts extra stress on the right pumping chamber of the heart, leading to eventual failure in the majority of the patients. Relieving these blockages reduces the stress put on the heart.
However there is limited data available to guide the cardiologist to identify the areas where balloon inflation maximises treatment effect. Not all patients respond to this treatment. It is unclear how many vessels should be treated and in which location to get the best results and improve right heart function. Measurement of right heart function, with a sensor that sits inside the heart measuring volume and pressure provides real-time feedback to the treating doctor. This as well as measuring biological markers in the blood may better identify responders to treatment and help guide future therapy.REC name
East of England - Cambridge South Research Ethics Committee
REC reference
18/EE/0162
Date of REC Opinion
13 Aug 2018
REC opinion
Further Information Favourable Opinion