GSC function to promote repair of gingival tissue
Research type
Research Study
Full title
Identification of novel routes to modulate Gingival Stem Cells (GSC) function to promote repair of gingival tissue.
IRAS ID
203019
Contact name
Keith Brennan
Contact email
Sponsor organisation
King's College, University of London
Duration of Study in the UK
5 years, 0 months, 0 days
Research summary
The study focuses on the cells isolated/derived from healthy and inflamed gum tissue, obtained during routine clinical procedure where this type of tissue is regularly discarded.
As previously reported, our mouth represents a real “treasure chest” for different stem cells, and our study focuses on the cells obtained from gum tissue, as easily accessible source of adult stem cells.
These cells will be isolated and optimal conditions for their growth and expansion “in vitro” will be established. Their stem cell properties will be maintained and studied, as well as the pathways and genes involved in their reparative properties.
We will be comparing cells isolated from healthy and inflamed tissue and use this information in further understanding of differences as well as properties of both types of tissues. These data will be of great importance for future development and translation of knowledge for “regenerative approaches” in the treatment of gum disease, as this disease is still first reason for tooth loss in the developed world.
Moreover, we will be using tissue, normally discarded in the clinics, and draw attention to it as a valuable source of stem cells.REC name
London - Surrey Borders Research Ethics Committee
REC reference
17/LO/1188
Date of REC Opinion
15 Sep 2017
REC opinion
Further Information Favourable Opinion