Grown in Wales
Research type
Research Study
Full title
The Grown in Wales Study: Developing a placentomic tool for characterising atypical pregnancies and predicting outcomes
IRAS ID
166243
Contact name
Richard JA Penketh
Contact email
Sponsor organisation
Cardiff and Vale University Local Health Board
Duration of Study in the UK
13 years, 0 months, 1 days
Research summary
Placental defects are associated with a wide range of the most common and most severe pregnancy complications in humans, such as miscarriage, preterm birth, preeclampsia and fetal growth restriction. Placental defects may also drive poorer outcomes for children and their mothers including behavioural disorders and diabetes. The aim of this research is to examine placentas (afterbirth) from both normal and atypical pregnancies in order to identify characteristics that are present in complicated pregnancies and to ask whether these characteristics can be used to predict outcomes for mothers and their children. This work is important as we can then begin to identify factors which may cause these changes and also develop biomarkers supporting the identification of at risk individuals for early intervention. We can also use these markers to quantitate the effectiveness of intervention strategies aimed at reducing the occurrence of pregnancy disorders and thus improving outcomes for both mothers and their children. In order to achieve these goals, it will be necessary to collect placentas, cord blood and saliva, questionnaire and medical data at delivery and to approach mothers and their children at later time points to obtain follow-up data.
REC name
Wales REC 2
REC reference
15/WA/0004
Date of REC Opinion
13 Feb 2015
REC opinion
Further Information Favourable Opinion