Grip-HD: Handgrip strength and physical ability in haemodialysis v1
Research type
Research Study
Full title
Is handgrip strength measurement predictive of future decline in activities of daily living in adults on haemodialysis?
IRAS ID
240182
Contact name
Lina Johansson
Contact email
Sponsor organisation
Imperial College London
Duration of Study in the UK
1 years, 5 months, 11 days
Research summary
Is handgrip strength measurement predictive of future decline in activities of daily living in adults on haemodialysis?
Haemodialysis (HD) is a treatment for people with end stage renal disease where dialysis is needed to support life. Most people undertake this treatment in hospital, three times a week for 4-5 hours.
Handgrip strength is a simple, inexpensive measurement used to determine muscle strength. Reference ranges for clinically significant weakness have been developed in older people and different clinical conditions, but not in people on HD. HD is associated with being significantly weaker than seen in other clinical conditions or in healthy older people.From our previous study in >400 people on HD, we developed an equation “Handgrip Strength Index”(%) using height, sex, age and ethnic background to determine an individual’s expected handgrip strength compared to their observed handgrip strength.
Handgrip strength has been shown to be related to physical function and to activities of daily living (e.g. bathing, cooking) in people without a kidney condition. However, it has been reported that 95% of people aged ≥65 years on haemodialysis have some difficulty with performing activities of daily living (ADL). Being independent and able to perform ADL is very important to people. Therefore, this research will explore if handgrip strength is related to the ability to undertake these activities.
This study aims to determine if handgrip strength is predictive of changes in ADL over 9-12 months in people aged ≥ 50 years on HD dialysing at Imperial NHS Trust. We also want to explore the relationship between handgrip strength, muscle mass and quality and nutritional status over time.
The two assessments (baseline and 9-12 months later) will take place during the participants usual HD session attendance and will be conducted either before their session starts or during the HD session.
REC name
South Central - Hampshire A Research Ethics Committee
REC reference
17/SC/0688
Date of REC Opinion
8 Feb 2018
REC opinion
Further Information Favourable Opinion