Greyzone Resistance and Flow with 3T MRI (GRAFT STUDY)
Research type
Research Study
Full title
A prospective comparison of the diagnostic utility of invasive coronary physiological indices and quantitative perfusion MRI in patients with coronary heart disease and indeterminate (grey-zone) fractional flow reserve values.
IRAS ID
165552
Contact name
Barry Hennigan
Contact email
Sponsor organisation
Golden Jubilee Research Institute
Duration of Study in the UK
3 years, 0 months, 0 days
Research summary
FFR is a method of using pressure waves in coronary arteries (the vessels supplying blood to the heart muscle) to estimate blockage severity. It has proven benefits in selecting those not requiring treatment as well as those most likely to benefit from treatment involving a procedure to open a blockage with insertion of a metal tube or stent in the artery.. A group of patients are considered indeterminate as regards their FFR values and they may be overtreated with current practice. We aim to assess these patients with new devices to measure pressure, flow and resistance in their vessels in order to potentially make the most accurate decision regarding their treatment and in order to create a new treatment pathway for these difficult cases. We will also carry out an MRI scan in the patients with indeterminate FFR as a gold standard looking for areas of poor blood supply to compare with our measurements made during the patient's angiogram . This MRI scan doesn’t involve any radiation. Following the initial assessment patients will be randomly allocated to angioplasty and stent insertion versus medical therapy and will be followed up for health outcomes using telephone interview and questionnaire.
REC name
South East Scotland REC 01
REC reference
14/SS/1099
Date of REC Opinion
5 Dec 2014
REC opinion
Unfavourable Opinion