Gravity Study
Research type
Research Study
Full title
The effect of GRAVITY on physiological measurements during invasive coronary angiography and intervention
IRAS ID
217882
Contact name
John Davies
Contact email
Sponsor organisation
Basildon and Thurriock University Hospitals NHS FT
Duration of Study in the UK
1 years, 3 months, 29 days
Research summary
Gravity Study: the effect of GRAVITY on physiological measurements during invasive coronary angiography and intervention.
What? The proposed study will address whether a change in patient position affects pressure and flow measurements in coronary arteries during a coronary angiogram. We will take measurements when patients are lying supine and repeat measurement when lying prone. There will be two groups of patients. The groups will be stable outpatients who will present for a day case procedure. These two groups will have differing coronary anatomy, but the procedure will be the same.
Why? This research is important to prove the concept that blood flow to certain areas of heart muscle can differ based on position. Therefore a patient suffering a heart attack may benefit from lying in a certain position to increase blood flow to the area affected and reduce the size of the heart attack.
Who? Patients suffering from coronary artery disease will be eligible based on inclusion and exclusion criteria.
Where: The study will be conducted at the Essex Cardiothoracic Centre only.
How: The study will last 18 months. The participants will undergo a standard care coronary angiogram with a pressure wire measurement or stenting / balloon treatment, plus further measurements on the table after changing position. This will add a maximum of 10-15 minutes to the procedure.
REC name
East of England - Cambridge South Research Ethics Committee
REC reference
17/EE/0003
Date of REC Opinion
16 Mar 2017
REC opinion
Further Information Favourable Opinion