*GOLDILOX-TIMI 69
Research type
Research Study
Full title
A Phase IIB, Randomized, Double blinded, Placebo controlled, Parallel group Study to Evaluate the Efficacy and Safety of MEDI6570 in Participants with a Prior Myocardial Infarction, Persistent Inflammation, and Elevated N terminal Prohormone Brain Natriuretic Peptide
IRAS ID
1003997
Contact name
Anna Ravnefjord
Contact email
Sponsor organisation
AstraZeneca AB
Eudract number
2020-000840-75
Clinicaltrials.gov Identifier
Research summary
The purpose of this study is to learn more about the effects that an experimental study drug called MEDI6570 can have on patients who have had a recent heart attack. This study will help us better understand heart disease in addition to seeing if MEDI6570 can help to reduce cholesterol blockages (atherosclerosis) in the blood vessels supplying blood to the heart.
About 800 people will take part in this study and taking part is entirely voluntary. The study lasts for approximately 15 months and in this time period, participants will have 16 visits. Additional visits may be necessary if further follow-up is needed. The duration of each visit may be different in length, at most lasting a few hours.
The study includes the following tests and procedures:
• A full physical exam
• Measurement of vital signs (blood pressure and heart rate), height and weight measurements
• Blood and urine samples
• An electrocardiogram (ECG) will measure the electrical activity of your heart
• Computed tomography angiography (CTA) scan, which involves injecting a dye into the blood stream, to produce complete images of the blood vessels and tissues around your heart.
• An echocardiogram will be performed using ultrasound to measure the heart’s function and size.
• Two extra urine samples are optional in this study. These optional urine samples will be used to answer questions in future research.REC name
East of England - Cambridge South Research Ethics Committee
REC reference
22/EE/0188
Date of REC Opinion
5 Oct 2021
REC opinion
Further Information Favourable Opinion