glycosylation patterns of glycodelin in patients with infertility 

• Research type

  Research Study

• Full title

  A prospective study to evaluate the glycosylation patterns of glycodelin in patients presenting with infertility 

• IRAS ID

  156435

• Contact name

  Linda Ibeto

• Contact email

  libeto@doctors.org.uk

• Sponsor organisation

  Chelsea and Westminster Hospital NHS Foundation Trust

• Research summary

  The study aims to look at the glycosylation of the protein glycodelin, found in the reproductive tract and seminal fluid.  This will involve collection of human follicular fluid, cumulus and granulosa cells, obtained at egg collection, seminal fluid from semen analysis, fluid from fallopian tubes collected during diagnostic laparoscopy, and endometrial tissue from diagnostic hysteroscopy or pipelle endometrial scratch around time of implantation.

  The glycodelin properties of each samples will be analysed.  A number of these proteins are thought to be important in the protection of gametes and embryos from maternal immunological attack. Glycodelin can be differentially glysosylated, which may enhance or reduce its immunosuppressive effect.

  We propose to define the variation in glycodelin glycosylation in infertile patients, to establish whether alterations in glycodelin glycosylation influence the outcome of IVF. 
  

• REC name

  North of Scotland Research Ethics Committee 2

• REC reference

  14/NS/1001

• Date of REC Opinion

  26 Jun 2014

• REC opinion

  Further Information Favourable Opinion