Glycaemic influences on FGF23/PTH/Vitamin D in Diabetes
Research type
Research Study
Full title
Exploring potential relationships in the FGF23/PTH/Vitamin D axis with varying glycaemic control in diabetes.
IRAS ID
178071
Contact name
Yee Ping Teoh
Contact email
Sponsor organisation
Betsi Cadwaladr University Health Board
Duration of Study in the UK
1 years, 0 months, 0 days
Research summary
The study is to investigate potential relationships between FGF23 and HbA1c levels in type 2 diabetics. The study will also be investigating 25-OH Vitamin D and PTH levels in this group while also testing for ALP, Calcium, Albumin, Phosphate, Urea and Creatinine with calculated estimated glomerular filtration rate (eGFR). It is intend to measure all these parameters as changes in these parameter are known to cause or be associated with changes in others (e.g Calcium and PTH) thus may impact on my principal measurements of interest to compare with HbA1c levels which are FGF23, PTH, 25-OH Vitamin D.
There are two main avenues to explore which are:
Are FGF23 levels increased with increasing HbA1c (Worsening glycemic control)?
Are decreased 25-OH Vitamin D levels associated with an increase in FGF23 levels in type 2 Diabetes?REC name
North West - Preston Research Ethics Committee
REC reference
15/NW/0701
Date of REC Opinion
22 Sep 2015
REC opinion
Further Information Favourable Opinion