Glycaemic Index Dietary Education for glucose abnormalities in CF
Research type
Research Study
Full title
GLIDE: Glycaemic Index Dietary Education for glucose abnormalities in cystic fibrosis - a feasibility study
IRAS ID
243817
Contact name
Laura Birch
Contact email
Sponsor organisation
University of Bristol
Duration of Study in the UK
1 years, 6 months, 30 days
Research summary
Cystic fibrosis (CF) is the most common life-limiting, genetic disease in white populations. Thick, sticky mucus causes organ obstruction, mainly affecting the lungs and digestive system. Few people with CF have normal blood glucose control and these glucose abnormalities eventually progress to cystic fibrosis-related diabetes (CFRD), the most common complication of CF. The combination of diabetes and CF leads to increased morbidity and a six-fold increase in mortality. \n\nPeople with CF are encouraged to consume a high calorie diet to maintain weight. This typically means eating food and drinks that are often high in fat and/or sugar. For people with CF who also need to control their blood glucose levels, high sugar intake can make this difficult. There is limited evidence to guide dietary therapy for blood glucose abnormalities in CF. Manipulating the glycaemic index (GI) and glycaemic load (GL) of what is consumed may be a possible area for intervention to improve blood glucose control without compromising energy intake. \n\nThis study will explore the feasibility of delivering glycaemic index/glycaemic load dietary education (GLIDE) in a sample of 20 young people with CF and abnormal blood glucose control. GLIDE intervention will be implemented by participants for 12 weeks. Dietary intake and glycaemic control will be measured at baseline and at 12 week follow-up using an on-line dietary recording tool and continuous glucose monitoring, respectively. \n\nThe primary objective of this study is to investigate the feasibility of GLIDE intervention in young people with CF and abnormal blood glucose control. Feasibility will be assessed through measurement of recruitment to the study, attendance at research visits and acceptability of GLIDE intervention, determined via in-depth qualitative interviews. Secondary objectives include measuring glycaemic control, energy and nutrient intake, body weight and lung function before GLIDE intervention and at 12-week follow-up.\n\n\n\n\n
REC name
South West - Central Bristol Research Ethics Committee
REC reference
18/SW/0105
Date of REC Opinion
1 Jun 2018
REC opinion
Further Information Favourable Opinion