Glucose Monitoring in OSA (GlucoMOSA)
Research type
Research Study
Full title
Continuous Glucose Monitoring in OSA; A Randomised Continuous Positive Airway Pressure Withdrawal Trial
IRAS ID
298699
Contact name
Christopher Turnbull
Contact email
Sponsor organisation
University of Oxford / Research Governance, Ethics and Assurance
ISRCTN Number
ISRCTN26117790
Duration of Study in the UK
1 years, 11 months, 31 days
Research summary
This study aims to understand the effects of obstructive sleep apnoea (OSA) on blood sugar levels, which cause complications in diabetes.
Type 2 diabetes mellitus (T2DM) and prediabetes both cause high blood sugar levels. Obstructive sleep apnoea (OSA) is a breathing condition that causes loud snoring and pauses in breathing during sleep. Whilst OSA is linked with high blood sugar levels in patients with T2DM and prediabetes, it is not known whether OSA is the cause of high blood sugar levels in these patients. Continuous positive airway pressure (CPAP) is the main treatment for OSA. CPAP is a snug-fitting face mask that attaches to a machine that blows air to hold the upper airway open and is worn during sleep. One way of proving that OSA effects blood glucose levels is by showing that CPAP treatment improves blood glucose control.
Participants will be patients with either T2DM or prediabetes, and OSA already on CPAP treatment. We will ask participants to briefly use sham CPAP instead for one week. During this week we will ask participants to wear a continuous glucose monitor, which is patch attached to the forearm or abdomen with a small needle less than the width of a hair. As a comparison, participants will also be asked to wear a continuous glucose monitor for one week with a study CPAP machine which will deliver effective CPAP treatment. The order in which participants receive or effective CPAP treatment will be randomised. We will also collect blood samples before and after both sham and effective CPAP.Stopping CPAP is not a major concern as many patients stop their CPAP for 1-2 weeks, such as when they have a cold or when they are on holiday. We conducted a survey of patients with OSA and over 60% of respondents would be willing to consider briefly stopping CPAP for research purposes.
We aim to see if OSA causes high blood sugar levels. This is an important step to understanding if treating OSA might improve the long-term health of patients with OSA who have diabetes or prediabetes.REC name
London - Dulwich Research Ethics Committee
REC reference
22/LO/0427
Date of REC Opinion
20 Jul 2022
REC opinion
Further Information Favourable Opinion