Global longitudinal strain of left ventricle in NSTEMIs

• Research type

  Research Study

• Full title

  The prognostic value of global longitudinal strain of the left ventricle in the risk assessment of patients with non-ST elevation myocardial infarction

• IRAS ID

  169881

• Contact name

  Kalliopi/KK Keramida

• Sponsor organisation

  Imperial College Healthcare NHS Trust

• Duration of Study in the UK

  1 years, 0 months, 1 days

• Research summary

  Non-ST elevation myocardial infarctions (NSTEMI), constitute the majority of acute coronary syndromes and encompass a wide range of events with a very diverse prognosis. NSTEMIs may have lower in-hospital mortality than STEMIs, but they have equal rates in 6 months and double mortality rate at 4 years. Risk assessment based on clinical history and examination, electrocardiographic characteristics and markers of myocardial damage, still remains relatively inaccurate and in a respectable rate, fail to identify high risk patients with substantial infarction, not receiving acute revascularization therapy.
  Infarct size, as well as the presence of an occluded artery, has been shown to correlate with global longitudinal left ventricular strain (GLS) in STEMI and NSTEMI, associated closely with the prognosis. Moreover the role of GLS in the prediction of all-cause mortality, heart failure admissions and LV recovery and remodeling is the subject of great interest in terms of outcomes, specifically in patients with NSTEMI.
  The aim of our study will be to test the hypothesis that GLS can identify high-risk patients with NSTEMI in the emergency department over and above the clinical and laboratory parameters that are currently used. Our ultimate goal will be to identify the best timing of reperfusion therapy in all high risk patients to improve their prognosis.

• REC name

  London - Westminster Research Ethics Committee

• REC reference

  15/LO/1351

• Date of REC Opinion

  19 Oct 2015

• REC opinion

  Further Information Favourable Opinion