GlasVEGAs:GlasgowVisceral&Ectopic fat with weight Gain in South Asians
Research type
Research Study
Full title
The GlasVEGAs study: Glasgow Visceral & Ectopic fat with weight Gain in South Asians
IRAS ID
209994
Contact name
Naveed Sattar
Contact email
Clinicaltrials.gov Identifier
Duration of Study in the UK
1 years, 8 months, 1 days
Research summary
South Asians have a much higher risk of diabetes compared to Europeans and investigators don't know why this is. Investigators think that South Asians' capacity to store fat safely under the skin is lower than Europeans, so they start to store fat around internal organs and in liver and muscle, and at lower body weights than Europeans. These increased levels of internal fat storage are thought to increase risk of diabetes.
The purpose of the study therefore is to investigate whether there are differences with weight gain and weight loss in fat storage, fat cell function and diabetes risk factors, in South Asians compared with Europeans. Investigators will compare South Asian and European men at the start of the study, after they have gained about 7% body weight, and again after they have lost 7-15% body weight (from peak weight) to see how gaining and losing weight affects fat storage within the body and the function of fat cells. Investigators will also assess the effect of weight gain and weight loss on metabolism, fitness and risk factors for diabetes and heart disease.
REC name
West of Scotland REC 3
REC reference
16/WS/0217
Date of REC Opinion
18 Nov 2016
REC opinion
Further Information Favourable Opinion