Genomics and Proteomics in Coronary Artery Disease (Version 1.0)
Research type
Research Study
Full title
Genomic & Proteomic Characterization of Patients with Single Vessel versus Multivessel Coronary Artery Disease
IRAS ID
239149
Contact name
Michael Mahmoudi
Contact email
Sponsor organisation
University Hospital Southampton NHS FT
Duration of Study in the UK
0 years, 6 months, 30 days
Research summary
The progressive deposition of cholesterol along the wall of one or more of the three main arteries that supply the heart muscle can eventually lead to the restriction of blood flow causing patients to experience chest pain when they exert themselves. This condition is called angina.
Although the molecular mechanism that underpins this process has been well described, it remains a mystery as to why some patients develop narrowing along one artery whilst others develop narrowing along two arteries and yet others develop narrowing along all three major arteries that supply the heart muscle. The aim of this project is to determine whether differences in the protein (proteomics) and genetic (genomic) build up of patients with narrowing affecting one artery is different to those with narrowing affecting two or three arteries.
REC name
London - Riverside Research Ethics Committee
REC reference
18/LO/0535
Date of REC Opinion
29 Mar 2018
REC opinion
Further Information Favourable Opinion