Genomic evolution of proliferative verrucous leukoplakia

• Research type

  Research Study

• Full title

  Genomic evolution from oral atypical verrucous hyperplasia to squamous cell carcinoma

• IRAS ID

  237068

• Contact name

  Eranga Nissanka-Jayasuriya

• Contact email

  e.nissanka-jayasuriya@nhs.net

• Sponsor organisation

  East Kent Hospitals University NHS Foundation Trust

• Duration of Study in the UK

  2 years, 0 months, 1 days

• Research summary

  Oral cancer death rates are on the rise (1) and there is a need to reduce the number of cases which transform to cancer by early diagnosis. Oral cancer can develop from oral precancer conditions which are difficult to diagnose early. Oral atypical verrucous hyperplasia(AVH) is a type of oral precancer which can show sudden transformation to aggressive cancer over the course of the disease, giving rise to multiple cancers. AVH is currently under-diagnosed as definite diagnostic criteria had not been identified. A recent gene sequencing study (2), highlighted that AVH is characterised by a different genetic profile to known oral precancers, which may explain the reason for its aggressive behaviour. The main aim of our study is to map the path of genetic change from AVH to cancer, which would aid early diagnosis. This will reduce the need for radical surgery and improve patient outcome.
  The main investigator is part of the direct clinical care team (head and neck cancer team) of the participants recruited for this study. A provisional anonymised search on WHH pathology database has confirmed that EKHUFT pathology archives are likely to hold sufficient material for a preliminary study of this nature (see A 60 for more detail). The DNA extracted from these tissue samples will be analysed by gene sequencing (the most advanced method for the purpose at present) to detect whether a specific detectable gene marker can be identified.
  This will be a collaborative study between WHH and University of Southampton (UOS); the DNA extraction, part of the gene sequencing and bioinformatics analysis will be conducted at UOS. Part of the gene sequencing will be outsourced to Oxford Genomic centre. It will run between 01/03/18 to 01/03/20

• REC name

  North West - Greater Manchester Central Research Ethics Committee

• REC reference

  18/NW/0303

• Date of REC Opinion

  6 Jun 2018

• REC opinion

  Further Information Favourable Opinion