Geniculate artery embolization in knee OA
Research type
Research Study
Full title
Geniculate artEry embolisatioN in patiEnts with oSteoarthrItiS of the knee\n(GENESIS)
IRAS ID
237676
Contact name
Mark Little
Contact email
Sponsor organisation
University of Reading
Duration of Study in the UK
4 years, 0 months, 1 days
Research summary
Osteoarthritis (OA) of the knee is an extremely common and debilitating condition with no known cure. Treatment includes pain relief, physiotherapy, steroid injections, weight-loss programs, and joint replacement surgery. Moderate arthritis resistant to nonsurgical options, not yet severe enough to warrant surgery, presents a specific management challenge and justifies research into the area. Studies have shown that OA is mediated by increased vascularity and recent work has shown the benefit of embolising abnormal vessels within the knee to alleviate symptoms of OA. The current study will investigate the clinical success and safety of arterial embolisation in knee OA. Patients with knee OA will complete pain scores and quality of life questionnaires before and after blocking the abnormal vessels in their knees using tiny particles under x-ray guidance (embolization). Patients will also undergo MRI of the affected knee before the procedure and afterwards to assess structural change. The results of this feasibility study will be used to design a larger cohort study.
REC name
London - Bromley Research Ethics Committee
REC reference
18/LO/0335
Date of REC Opinion
19 Apr 2018
REC opinion
Further Information Favourable Opinion