Genetic variation in CLTCL1, other related genes & glucose control
Research type
Research Study
Full title
The role of genetic variation in CLTCL1 and other related genes in relation to whole-body glucose control: A pilot study.
IRAS ID
250113
Contact name
Aaron Hengist
Contact email
Sponsor organisation
University of Bath
Duration of Study in the UK
3 years, 0 months, 30 days
Research summary
Research Summary:
The ability to maintain relatively stable blood sugar levels after eating is an important marker of health. Our muscles play a major role in our ability to keep blood sugar levels in a healthy range. We want to understand what the role of some proteins found in our muscle cells have in relation to our ability to control blood sugar levels. These proteins are called "Clathrins" and some previous work in cell-based studies suggests that play an important role in controlling how much sugar our muscle take up out of the blood stream. However, we currently don't know if these cell-based studies have any relevance to humans. We do know that in the general population there is wide variation the genes relating to Clathrins. The aim of this study is to see if this genetic variation has any relevance to our ability to control blood sugar levels. We will ask healthy adult volunteers to come into the laboratory on a single occasion. During this visit we will ask these volunteers to drink a sugary drink, containing 75 g of glucose. We will take blood samples before and at frequent intervals for 2 hours after the ingestion of this drink, to assess people's ability to maintain stable blood sugar levels. In these blood samples we will also assess people genes to understand if certain variations in key genes are associated with a better ability to control blood sugar levels.Summary of Research:
Our data suggest that there is unlikely to be a major influence of variations in the gene "CHC22" on blood sugar control in healthy people.REC name
North West - Greater Manchester West Research Ethics Committee
REC reference
18/NW/0573
Date of REC Opinion
30 Aug 2018
REC opinion
Further Information Favourable Opinion