Genetic variation and mechanisms of inflammatory bowel disease
Research type
Research Study
Full title
Biological mechanisms of inflammatory bowel disease affected by genetic variation
IRAS ID
166440
Contact name
Arthur Kaser
Contact email
Duration of Study in the UK
3 years, 0 months, 0 days
Research summary
Inflammatory bowel disease affects over one in five hundred individuals in western populations. Recent studies have identified a number of genetic markers (polymorphisms) which are associated an increased risk of Crohn's disease and ulcerative colitis, two different forms of inflammatory bowel disease. However, the mechanisms by which these polymorphisms increase disease susceptibility is incompletely understood. This study will investigate how genetic polymorphisms affect parameters of immune cell function in healthy volunteers. This will increase our understanding of the molecules and pathways that regulate immune cell function, and how these are altered in disease. Ultimately, this may provide insights into novel biomarkers and targets for therapy.
REC name
South Central - Berkshire B Research Ethics Committee
REC reference
15/SC/0068
Date of REC Opinion
26 Jan 2015
REC opinion
Favourable Opinion