Genetic variants and regulation of specialized pro-resolving mediator
Research type
Research Study
Full title
Identifying the effect of genetic variants on specialized pro-resolving mediators and their association with chronic inflammatory conditions
IRAS ID
291815
Contact name
Jesmond Dalli
Contact email
Sponsor organisation
Queen Mary University of London
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Inflammation is the way that the body reacts against infection, injury or illness. An uncontrolled inflammatory response can lead to the development of inflammatory diseases, such as rheumatoid arthritis and cardiovascular conditions. Recent studies have shown that inflammation is a regulated process coordinated by a group of molecules known as specialized pro-resolving mediator (SPM). These molecules are produced by enzymes via the enzymatic conversion of essential fatty acids; whereas their biological actions are mediated by proteins expressed on the surface of cells known as receptors.
Given the central role that pro-resolving mediators play in regulating the immune response, the aim of this study is to investigate whether there are genetic variants (mutations) in genes encoding for enzymes and receptors involved in the biology of these molecules and to determine how these mutations affect SPM's activity or function.
Findings made as part of these studies will help shed light into mechanism influencing disease onset and/or progression and potentially enhance the discovery of new and more effective treatments.
REC name
London - Riverside Research Ethics Committee
REC reference
21/LO/0189
Date of REC Opinion
18 Mar 2021
REC opinion
Further Information Favourable Opinion