Generation and validation of in vitro human cell models
Research type
Research Study
Full title
Generation and Validation of Human Cell Types for Drug Discovery
IRAS ID
293233
Contact name
Gianmarco Mastrogiovanni
Contact email
Duration of Study in the UK
10 years, 0 months, 1 days
Research summary
The aim of this study is to generate functional cells that mimic human cells - both normal healthy cells as well as disease model cells. The goal is to create cell models for a variety of human cell types that resemble and function as close as possible to the living human cells (cells in vivo). This would enable bit.bio to provide normal and disease model cells for the purpose of research and applications such as examining the therapeutic effect of novel therapies or potential therapeutic substances and for the development of therapies and therapeutic strategies to combat disease.
Bit.bio is aiming to produce or generate such cells using Induced Pluripotent Stem Cells (IPSC’s) which through this research will be encouraged to differentiate and generate the specialised cells described above such as immune, blood, cardiovascular, neuronal, bone, and gastrointestinal system cells. The IPSC’s will be obtained through the following three routes:
I. Donated primary human cells from authorised and approved commercial or non-commercial suppliers (e.g. academia) shall be used to create IPSC’s which in turn will be used for the production of the cells described above
ii. Use IPSC’s from previous research activities and maintained at bit.bio, to produce the cells described above
iii. Use commercially available IPSC’s from licensed and authorised distributors or collaborators to create the cells described above.REC name
London - Surrey Research Ethics Committee
REC reference
21/PR/0766
Date of REC Opinion
15 Jun 2021
REC opinion
Favourable Opinion