Generation and Banking of Research Grade iPSC lines

• Research type

  Research Tissue Bank

• IRAS ID

  165422

• Research summary

  European Bank for Induced Stem Cells (EBiSC)

• REC name

  Scotland A: Adults with Incapacity only

• REC reference

  16/SS/0080

• Date of REC Opinion

  20 Jun 2016

• REC opinion

  Further Information Favourable Opinion

• Data collection arrangements

  Consent forms and donor information will be transfered to the NHS Clinical Research Facility (CRF Edinburgh) who will manage the consenting in the case of Generation Scotland and SHARE donors or associated clinical units having contact with donors in the case of non-GS/SHARE donors.

  GS/SHARE donor samples will be taken and briefly stored (prior to transfer to Roslin Cell Sciences) by CRF Edinburgh at one of their 3 facilities either at the Royal Infirmary of Edinburgh (RIE), Western General Hospital (WGH) or Royal Hospital for Sick Kids (RHSC), Edinburgh. In exceptional cases, CRF Edinburgh community research nurses will be able to visit donors in their own homes as part of a home visit if they are unable to attend at one of the 3 CRF Edinburgh facilities.

  Once at Roslin Cell Sciences, the samples will either be processed immediately to make stem cell lines or processed for cell storage until the stem cell derivation work can commence. Storage will be within the Roslin Cell Sciences labs at the Roslin BioCentre, Roslin, EH25 9PP.

  Cell line associated data will be stored on the Information Management System to enable it to be made available to researchers. It will not contain any personal details that could enable the identification of the original tissue donor.

• Research programme

  The EBiSC bank will make human stem cell lines available to academic and commercial scientists worldwide. The lines will be derived from a wide range of diseases so that users may differentiate the cells and establish human disease models "in a dish" as an alternative to using animal models which are often not very representative of the human disease. As well as disease based lines, there will also be a large number of control lines from non-affected individuals. A key strength of the Generation Scotland collaboration is that their database contains many family members, whose samples can help research by providing familial control lines. In time, the bank will also hold genetically edited stem cell lines in which either a disease-causing mutation has been corrected (to give an "isogenic control") or a disease-causing mutation has been inserted into a normal line to generate a genetically edited disease line. These new types of stem cell line will help us better understand the causes of many poorly understood diseases. Pharmaceutical companies will be able to use EBiSC cells to make any cell type they need to test new drugs on either for efficacy studies or toxicity tests.

• RTBTitle

  European Bank for Induced Stem Cells (EBiSC)

• Establishment organisation

  Roslin Cell Sciences

• Establishment organisation address

  Roslin BioCentre

  Roslin

  EH25 9PP