Gene expression profiles in muscle after immunisation
Research type
Research Study
Full title
A clinical study to generate an exploratory training set of data on the time course of the gene expression profile at the site of antigen deposition compared with whole blood following intra-muscular injection with alum or MF59-adjuvanted protein subunit vaccines
IRAS ID
169961
Contact name
Aldona Greenwood
Contact email
Sponsor organisation
University of Surrey
Duration of Study in the UK
2 years, 1 months, 24 days
Research summary
This clinical study is part of a series which have been designed to improve our detailed understanding of how humans respond to vaccines. Normally only responses in blood are measured as it is convenient to sample. However, the cells in the blood fluctuate and may not accurately reflect what actually happens in the tissues where most of the immune response takes place. In this study we will take a small muscle biopsy in order to identify any differences in the response around the actual site of injection compared with responses we measure in blood at the same time. This will extend previous studies with similar vaccines where we measured the blood responses in great detail.
REC name
London - Surrey Borders Research Ethics Committee
REC reference
14/LO/2226
Date of REC Opinion
29 Dec 2014
REC opinion
Favourable Opinion