GEMINI-OS : platform informatics for data-driven neuromodulation
Research type
Research Study
Full title
GEMINI-OS : platform informatics for data-driven neuromodulation
IRAS ID
327169
Contact name
Francesca Morgante
Contact email
Sponsor organisation
City St George’s, University of London
Duration of Study in the UK
0 years, 11 months, 29 days
Research summary
Deep Brain Stimulation (DBS) is an established treatment for advanced Parkinson's disease (PD). PD is a progressive disease for which there are symptomatic treatments but no cure. In the advanced stages, medications can fail to control symptoms and commonly cause movement and non-movement related side effects. At this stage, people with PD can be referred to a DBS centre where a team of experts, including a neurologist and a brain surgeon, conduct extensive assessments before offering surgery.
While DBS can be a life-changing treatment, 1 in 4 patients fail to benefit from DBS and some even worsen following surgery. Conversely, some patients who would benefit from it are not offered treatment. Whilst technological improvements in the devices have massively improved the delivery of DBS treatment over the last 20 years, the ability to select the best candidates has remained static. We will recruit patients who are being assessed for their suitability for DBS surgery and patients who have already had their surgery. We will use the data collected as standard of care for these patients, with an optional extra functional MRI, to develop a new clinical tool which will facilitate and improve patient selection for DBS.
We will develop a novel platform that combines data from before and after surgery to determine what factors predict a good or poor outcome from surgery. Providing a data-driven, objective tool for patient selection, will improve the process by: 1) reducing the number of people who will deteriorate following surgery; 2) increasing the number of people who are offered treatment, including those in the earlier stages; 3) giving clinicians greater confidence in the selection process and potentially allow more patients to benefit.
REC name
East Midlands - Derby Research Ethics Committee
REC reference
25/EM/0053
Date of REC Opinion
17 Feb 2025
REC opinion
Further Information Favourable Opinion