Gastric emptying GS MRI
Research type
Research Study
Full title
Validation of a test meal across different imaging platforms: GS and MRI
IRAS ID
210911
Contact name
Gordon Moran
Contact email
Sponsor organisation
University of Nottingham
Duration of Study in the UK
0 years, 11 months, 30 days
Research summary
We have been using a standard soup test meal to elicit postprandial gastrointestinal responses (e.g. motility, transit, plasma peptides) in healthy volunteers (UoN SoM LREC approval H19062014) and patients with Crohn’s disease (NRES approval 15/EM/0003 and R&D approval 14GGA043) using magnetic resonance imaging (MRI). We wish to extend the soup test meal translational use by validating its gastric emptying performance on a different imaging platform such as gamma scintigraphy (GS).
Therefore we plan to feed the same soup meal, radiolabeled with a small amount of 99mTc, to a group of healthy volunteers and measure their gastric emptying on a MRI scanner and a gamma scintigraphy camera on the same day, alternating the two techniques through the emptying of the meal, in a 1-way study and later compare the gastric emptying curves. There are currently no validation studies of MRI versus gamma scintigraphy carried out concurrently on the same day hence this aspect of the study is also novel.
REC name
East Midlands - Nottingham 2 Research Ethics Committee
REC reference
17/EM/0151
Date of REC Opinion
22 Jun 2017
REC opinion
Further Information Favourable Opinion