Gait Analysis in EB Simplex
Research type
Research Study
Full title
Gait Analysis in Epidermolysis Bullosa Simplex
IRAS ID
274099
Contact name
Deborah Falla
Contact email
Sponsor organisation
University of Birmingham
Clinicaltrials.gov Identifier
N/A, N/A
Duration of Study in the UK
0 years, 5 months, 17 days
Research summary
Summary of Research
Epidermolysis bullosa (EB) comprises a group of at least 30 separate conditions each associated with a unique gene abnormalities, and all sharing the common problem of blistering in relation to trauma, often mild and in particular related to shear force The commonest group, comprising approximately 70% of all patients, is the group termed Epidermolysis Bullosa Simplex, who amongst other problems have reduced moblity and poor posture. We wish to analyse gait and dynamic foot pressures in adults with Epidermolysis bullosa simplex, and then develop personalised rehabilitation therapies to correct abnormalities, combined with orthotics provided by the half national UK EB Service, based at Solihull HospitalSummary of Results
This study investigated how people with Epidermolysis Bullosa (EB) Simplex walk, and a comparison with a group of healthy individuals was conducted. The mediolateral and anteroposterior forces produced by the contact of feet with the ground were reduced in people with EB simplex during the heel strike and push-off phases of their walking cycle. Also, people with EB simplex walk with a shorter step length. Significant kinematics differences were not observed between people with EB simplex and the control group, but large heterogeneity was observed in people with EB simplex which could explain why statistical differences between groups were not identified. Findings of this study can inform future projects applying potential interventions to restore a correct gait pattern in people with EB simplex.REC name
London - Brent Research Ethics Committee
REC reference
20/PR/0013
Date of REC Opinion
27 Jul 2020
REC opinion
Favourable Opinion