FUTURE AS Registry
Research type
Research Study
Full title
Feasibility and Utility of Anatomical and Physiological Evaluation of Coronary Disease with Cardiac CT in Severe Aortic Stenosis
IRAS ID
308648
Contact name
Timothy Fairbairn
Contact email
Sponsor organisation
Centre for Cardiovascular Innovation (CCI)
Duration of Study in the UK
0 years, 6 months, 1 days
Research summary
"Research Summary"
Transcatheter Aortic Valve Replacement (TAVR) is increasingly used to treat severe symptomatic aortic stenosis (AS). As part of the planning and workup for this procedure patients require a cardiac computed tomography (CCT) scan. The majority of hospitals also assess the coronary arteries by performing an invasive coronary angiogram (ICA). However, information about the coronary arteries can be derived from the CCT. The FUTURE AS study is designed to look at whether a CCT scan alone is safe and accurate for guiding the TAVR without having to expose the patient to additional ICA."Summary of results"
Computed tomography coronary angiography was performed in 327 severe aortic stenosis patients. It was safe (4 patients developed low blood pressure) and accurate. FFRCT when performed improved the accuracy versus invasive angiography on a patient and vessel level. Using a CCTA and FFRCT approach could avoid 8 out of 10 invasive angiograms.REC name
Wales REC 7
REC reference
22/WA/0116
Date of REC Opinion
16 Jun 2022
REC opinion
Further Information Favourable Opinion