Functional Network Dynamics in Parkinson’s Disease: Version 1
Research type
Research Study
Full title
Probing Functional Network Dynamics in Early Stage Parkinson’s Disease
IRAS ID
196785
Contact name
Adam Hampshire
Contact email
Sponsor organisation
Imperial College London
Duration of Study in the UK
6 years, 0 months, 23 days
Research summary
Parkinson’s Disease (PD) is a common progressive neurodegenerative disorders in older adults. The detrimental effect of PD on the motor system has been the focus of much research. However, the impact that it has on cognition is less well understood. The cognitive effects have serious implications for a patient’s well-being and in the long-term can become a co-morbid qualifier for palliative care. It is known that there is heterogeneity in the onset and the progression of cognitive symptoms within PD populations. Therefore, a detailed understanding of how the brain systems of PD sub-groups differentiate in the early stage of the disease course will can help identify predictive markers and intervention targets.\n\nOur study has three goals. \n\n1. To identify the neural systems that underlie cognitive impairments during the early stages of PD using combined fMRI and EEG. \n\n2. To conduct repeated longitudinal measures using remote cognitive testing via the internet in order to track the heterogeneity of cognitive decline in PD. \n\n3. To identify predictive markers that can identify early stage PD patients who are at heightened risk of developing cognitive impairments.
REC name
London - Westminster Research Ethics Committee
REC reference
16/LO/0576
Date of REC Opinion
24 Mar 2016
REC opinion
Favourable Opinion