Functional and Radiomic Evaluation of Colorectal Liver Metastasis
Research type
Research Study
Full title
Functional and Radiomic Evaluation of Colorectal Liver Metastasis prior to Resection with Curative Intent: Correlation between imaging morphology and histological features (FILM-2)
IRAS ID
290372
Contact name
James Franklin
Contact email
Sponsor organisation
University Hospital Southampton
Duration of Study in the UK
4 years, 0 months, 3 days
Research summary
This study is focused on imaging of patients who have bowel cancer which has spread to the liver. The aim of the study is to improve and individualise treatment decisions for these patients so they have the best chance of survival.
Some patients with bowel cancer which has spread to the liver can have surgical removal of the cancer which has spread. Several studies have looked at the removed cancer and found microscopic details which could help make important decisions about treatment including having chemotherapy before surgery, what chemotherapy type, follow-up schedule and approach to surgery. Unfortunately this information is currently only available after surgery.
New imaging techniques including how patients are scanned and how the scans are read (including involvement of Artificial Intelligence) could provide all this information before the patient has any surgery.
For this study, patients will have an additional MRI scan with advanced techniques. This information will then be compared to the microscopic details of the cancer once it has been removed. We will then decide if these microscopic details are reliably picked up on the imaging.
REC name
Wales REC 6
REC reference
21/WA/0333
Date of REC Opinion
22 Oct 2021
REC opinion
Favourable Opinion