FULL-REVASC
Research type
Research Study
Full title
Ffr-gUidance for compLete non-cuLprit REVASCularization – a registry-based randomized clinical trial
IRAS ID
227143
Contact name
Colin Berry
Contact email
Sponsor organisation
Uppsala Clinical Research Center
Clinicaltrials.gov Identifier
Duration of Study in the UK
10 years, months, days
Research summary
A heart attack is caused by a sudden blockage in one of the main blood vessels supplying the heart. The blockage is revealed by a coronary angiogram with a view to reopening the artery and placing a stent (thin metal tube). About one half of all heart attack patients are found to have more than one narrowed heart artery. The best treatment approach for patients with multiple narrowings is not well established. The options include to treat all of the narrowings during the initial hospital stay or to defer treatment to only those patients with recurrent symptoms. Decision-making during the angiogram can be guided by measuring the drop in blood pressure across a narrowing. This test is called the fractional flow reserve (FFR). In this study we aim to assess whether a strategy of treating all narrowings with stents guided by the FFR test might improve patient well being and survival in the longer term compared to a more conservative approach. Each option represents different forms of standard care. The study is taking place in multiple countries, including Sweden, Denmark, Norway, Finland, Iceland, Latvia and Poland. 4052 heart attack patients will be enrolled at the time of the initial heart attack procedure. The results of this study will help to clarify which of the treatment approaches should be recommended in clinical practice.
REC name
West of Scotland REC 1
REC reference
18/WS/0104
Date of REC Opinion
13 Aug 2018
REC opinion
Further Information Favourable Opinion