Frailty & INEquality in STroke (FINE-ST)
Research type
Research Study
Full title
Frailty, Inequality and Comorbidity: a cohort study in TIA and Stroke
IRAS ID
273619
Contact name
Tim England
Contact email
Sponsor organisation
University of Nottingham
Duration of Study in the UK
2 years, 0 months, 0 days
Research summary
Stroke is the commonest cause of neurological disability and death in the UK (>100,000 per year). The majority of strokes occur in the older generation (58% aged >70), whilst over one third (38%) occur in middle-aged adults.
Risk of TIA and stroke are increased in the older population, both age and frailty negatively impacting on outcomes. However, the influence of frailty on stroke outcomes (including physical function and cognition) is not well understood.Second, the association between death from cardiovascular disease (including stroke) and health inequality is also stark with greater inequality associated with worse outcomes from heart attacks and strokes. It is therefore important to understand how diversity and inequality across the region relate specifically to mini-strokes (transient ischaemic attack, TIA) and strokes.
We therefore plan to identify patients assessed through the rapid access TIA clinics and stroke units in the East Midlands with the aim to explore the relationships between frailty, co-morbidity, health inequality and clinical outcomes. This information will help inform future trial design in the frail elderly population with stroke and enable us to tailor more appropriate, potentially cost saving approaches to treatment.
The study simply collects information through administration of a questionnaire at two time points (baseline and 90 days later) in two groups (within 6 weeks of the TIA/stroke; and >6 weeks of the TIA/stroke). The questionnaire at baseline is administered either face-to-face whilst in hospital, or sent via the post if the participant is at home. The questions asked 90 days later will be performed over the telephone.
REC name
Wales REC 1
REC reference
20/WA/0039
Date of REC Opinion
18 Mar 2020
REC opinion
Further Information Favourable Opinion