Fosfomycin resistance in multi-resistant Enterobacteriaceae
Research type
Research Study
Full title
Molecular mechanisms of fosfomycin resistance in multi-resistant uropathogenic Enterobacteriaceae
IRAS ID
150785
Contact name
Magda Iwanczuk
Contact email
Sponsor organisation
University of Chester
Duration of Study in the UK
0 years, 8 months, 1 days
Research summary
The main objective of this study is to clarify the molecular mechanisms of fosfomycin resistance in urinary pathogens isolated locally (in Gloucestershire). Fosfomycin is an old, broad spectrum antibiotic, that has been exclusively used for Urinary Tract Infection (UTI) treatment for decades. It achieves high urinary concentrations after a single dose, it is well tolerated and has been judged as safe to use. Despite its wide and prolonged use, various studies have shown a low incidence of resistance to this agent. Areas with a history of extensive use of this antibiotic and those with no history of use showed equally low levels of resistance. This project aims to describe some of the mechanisms of resistance to fosfomycin. This will complement the existing knowledge of fosfomycin resistance genes and their prevalence. Growing evidence that fosfomycin would be useful in treatment and eradication of multi-resistant uropathogens may assist in bringing fosfomycin back into routine use in the UK.
REC name
East Midlands - Nottingham 2 Research Ethics Committee
REC reference
15/EM/0061
Date of REC Opinion
27 Jan 2015
REC opinion
Favourable Opinion