• Research type

    Research Study

  • Full title

    FOcused LongitudinaL Observational study to improve knoWledge of COVID-19



  • Contact name

    David Connell

  • Contact email

  • Sponsor organisation

    NHS Tayside

  • ISRCTN Number


  • Duration of Study in the UK

    6 years, 0 months, 1 days

  • Research summary

    Background: Severe COVID-19 infection can cause severe pneumonia and acute respiratory distress syndrome (ARDS) leading to a requirement for mechanical ventilation. It is also now recognised that it can cause inflammation of blood vessels which may lead to a longer term increased risk of cardiovascular disease. NHS Scotland must plan for the long term care of potentially thousands of patients who will experience long term complications of COVID-19, both within the lung and outside the lung. As COVID19 is a new disease, there is a need to identify the long term consequences and future care needs of COVID19 survivors.

    Eligibility: We wish to establish a national cohort of 300 people with COVID19.

    Outcomes: In this study we will use blood testing, urine, respiratory samples, and tests of blood vessel function to help determine the long term consequences of this disease and identify future management approaches. This will be through the current study and in the future with analysis of healthcare use.

    Specific interests will include the recovering epithelial function in the lungs; endothelial function relating to cardiovascular disease and diabetes; effects of COVID-19 on complications related to, and management of diabetes; characterising the microbiome of the airway epithelium after COVID-19; development of a biobank of samples to further research predictors of long term health outcomes; long term assessment of healthcare use following COVID disease.

  • REC name

    Yorkshire & The Humber - South Yorkshire Research Ethics Committee

  • REC reference


  • Date of REC Opinion

    16 Sep 2020

  • REC opinion

    Further Information Favourable Opinion