Foetal brain imaging in NF1
Research type
Research Study
Full title
Prenatal fetal brain development in Neurofibromatosis type 1 (EDEN-P) study
IRAS ID
302410
Contact name
Shruti Garg
Contact email
Sponsor organisation
University of Manchester
Duration of Study in the UK
1 years, 11 months, 31 days
Research summary
The aim of this project to study early brain development in Neurofibromatosis 1 (NF1) - a common genetic condition seen in 1:= in 2500 individuals. Children with NF1 have difficulties with learning, Autism Spectrum Disorder (ASD) and Attention Deficit Hyperactivity Disorder(ADHD). The aim of this project is to study the developing foetal brain from the third trimester of pregnancy onwards. This is a proof of concept, feasibility study which will recruit pregnant mothers with a family history of NF1 (n=8) with a view to collecting detailed ultrasound and foetal brain imaging in the third trimester. Babies born to the mothers recruited to this study will be invited to take part in the ongoing EDEN study(IRAS ID 200297). Qualitative interviews with the mothers will help us identify the feasibility and acceptability of our protocol. Foetal brain imaging is technically very challenging- due to foetal movement in the womb. Therefore, in order to develop our foetal brain scan protocol, we request recruiting healthy pregnant mother (n=8).
REC name
North West - Greater Manchester West Research Ethics Committee
REC reference
21/NW/0346
Date of REC Opinion
10 Jan 2022
REC opinion
Further Information Favourable Opinion