FLuid status Using bioImpedance Data / FLUID
Research type
Research Study
Full title
Assessment of response to furosemide therapy by bioelectrical impedance versus cumulative fluid balance recording
IRAS ID
326211
Contact name
Quen Mok
Contact email
Sponsor organisation
Great Ormond Street Hospital for Children NHS Foundation Trust
Duration of Study in the UK
0 years, 5 months, 31 days
Research summary
Fluid balance is an important component of any treatment to prevent under, or over hydration. Precise assessment of fluid status is crucial since inaccurate evaluation can lead to either overtreatment or undertreatment, both linked to higher death rates. Furosemide is commonly used in paediatric intensive care units to remove extra fluid accumulated in various body compartments. Fluid input and output calculation is the most widely used method to guide furosemide therapy. Unfortunately, this approach does not provide information about distribution of fluid across various body compartments. We need a reliable tool that can be used to direct furosemide therapy. The assessment of body composition and fluid status with the device that we are using can provide important information of hydration status and distribution of body water across various compartments.
This is a single centre study, to be conducted in the paediatric intensive care unit of Great Ormond Street hospital.
A total of 100 patients, from the age of 2 days to 15 years, will be recruited. Patients in the paediatric intensive care unit requiring intravenous furosemide for extra fluid in their body will be identified. A study team member will confirm the eligibility and follow the consent procedure. The study team member will record patient data, current fluid balance and take measurements at base line (zero hour). Similar observations will be recorded at 8 and 24 hours. The measurements will be done by a device using four electrodes attached on the hand and foot on one side of the body. This is a quick test and will not interfere with routine clinical care required for the patient. Data on kidney function including urine output and various tests, that are routinely done for these patients, will be recorded at 0 and 24 hours. No additional blood tests will be required.REC name
Yorkshire & The Humber - Leeds West Research Ethics Committee
REC reference
24/YH/0048
Date of REC Opinion
17 Jul 2024
REC opinion
Further Information Favourable Opinion