FLAME
Research type
Research Study
Full title
A randomised controlled, double blind trial investigating the efficacy of fluoxetine treatment in improving memory and learning impairments in patients with mesial temporal lobe epilepsy: Fluoxetine, Learning and Memory in Epilepsy (FLAME).
IRAS ID
137768
Contact name
William Gray
Contact email
Eudract number
2014-005088-34
Duration of Study in the UK
1 years, 11 months, 31 days
Research summary
Many people with temporal lobe epilepsy (TLE) have problems with their memory and with their ability to learn new things. This can reduce their quality of life. At the moment, there are no medicines or treatments available that can treat the memory and learning problems associated with TLE. This study has been designed to see if a treatment, which we know works in animal models of epilepsy, can also work in humans with TLE.
The aim of this study is to see if people with TLE can improve their memory and learning by taking a short course of a medicine called fluoxetine. This is a commonly prescribed antidepressant medicine, more commonly known by the trade name Prozac. It has been shown in an animal model of epilepsy that two months of treatment with fluoxetine can improve memory and learning. This study has been designed to see if we can see the same effect in humans.
REC name
Wales REC 3
REC reference
14/WA/1254
Date of REC Opinion
22 Jan 2015
REC opinion
Further Information Favourable Opinion