FICE-DC (VERSION 5)
Research type
Research Study
Full title
Flexible spectral Imaging Colour Enhancement for the detection of dysplasia in colitis.
IRAS ID
127767
Contact name
Chris Fraser
Contact email
Sponsor organisation
North West London Hospitals NHs Trust
Research summary
Patients with a longstanding history of Ulcerative Colitis or Crohn’s Colitis need regular endoscopic assessment of the large bowel to ensure there are no changes such as dysplasia (change in size, shape and pattern of normal cells) of the mucosa and polyps (small fleshy growths) that might predispose to the development of bowel cancer. Currently patients undergo regular surveillance colonoscopy with a dye spray test to identify these abnormal areas in the bowel. However this technique is time consuming, cumbersome and needs experienced endoscopists. There are promising new image enhancing technologies available to identify abnormal areas without the use of a dye. This study aims to evaluate whether one of these new techniques can replace the dye spray examination.
All patient who are referred to St Mark’s hospital to undergo a surveillance colonoscopy for colitis will be invited to take part in the study. When we send the colonoscopic examination appointment letter,we will send the invitation for the study with information leaflet.If they decide to take part the principal investigator will seek consent before the procedure.
Participant will undergo a colonoscopic insertion in a routine manner. On withdrawal of the colonoscope patients colonic lumen will be examined by two different methods. Firstly a segment of colon will be examined using a different coloured light (without dye) and tissue biopsies will be taken from any area of concern. The colonoscope will then re-examine the same segment after being sprayed by a blue colour dye and further tissue biopsies will be taken if needed (standard technique). The rest of the colon will be examined in a similar fashion. The procedure time will be prolonged by about 13-15 minutes compared to have a colonoscopy with dye spray or special light.Images of the bowel will be taken as per standard practice.
REC name
London - Bromley Research Ethics Committee
REC reference
13/LO/0803
Date of REC Opinion
19 Jun 2013
REC opinion
Favourable Opinion