Fermentable carbohydrate and gut hormone release

• Research type

  Research Study

• Full title

  Understanding the interplay between fermentable carbohydrates and gut hormone release

• IRAS ID

  214171

• Contact name

  Gary Frost

• Contact email

  g.frost@imperial.ac.uk

• Sponsor organisation

  Imperial College London

• Duration of Study in the UK

  3 years, 0 months, 1 days

• Research summary

  In England, 60% of the adult population is overweight or obese. There is an urgent need to understand how dietary components effect appetite regulation. Previous research has demonstrated that increased dietary intake of fermentable carbohydrate promotes weight loss. Fermentable carbohydrates are not digested in the small intestine (the ileum) and therefore enter the large intestine (the colon) where they are fermented by the resident bacteria producing short chain fatty acids (SCFAs). SCFAs have been shown to stimulate the release of appetite suppressing hormones called PYY and GLP-1 from the colon. The aim of the present study is to determine the effects of diets containing different amounts of fermentable carbohydrates on ileum contents and to determine the subsequent impact on appetite responses and PYY and GLP-1 release from the colon.

• REC name

  London - Bloomsbury Research Ethics Committee

• REC reference

  17/LO/0354

• Date of REC Opinion

  8 Mar 2017

• REC opinion

  Favourable Opinion