Feasibility@48
Research type
Research Study
Full title
Feasibility@ 48: A cross sectional multi-centre study of Intensive Care Unit (ICU) mobility practices across the United Kingdom.
IRAS ID
262426
Contact name
Eve Corner
Contact email
Sponsor organisation
University College London
Clinicaltrials.gov Identifier
Z6364106/2019/10/52, UCL Data Protection Registration
Duration of Study in the UK
0 years, 4 months, 1 days
Research summary
Intensive Care Unit (ICU) patients commonly experience muscle loss at a rate of 2-3% day. Traditionally, critically ill patients have been managed in bed, however current research suggests that prolonged bedrest cause mechanical silencing of the muscles and exacerbates this muscle wasting. This ICU acquired weakness (ICUAW) leads to poor functional outcome and higher mortality.
Research suggests that early out-of-bed mobiliation should occur within 48-hours of ICU admission to militate against this risk, however, this is only achieved in 30% of cases. Common barriers to mobilisation are unstable blood pressure, ventilation, sedation and fatigue. It is plausible that 48-hours is an unrealistic timeframe for mobilisation.
The aim of this study is to explore the mobility practices on a given day in UK adult ICUs. The objectives are to:
1. Determine the level of mobility that is achieved by each patient on adult ICUs, on a given day in the UK.
2. Determine the typical physiological profile of patients on ICU that are both able and unable to participate in antigravity exercise
3. Determine the proportion of adult ICU admissions that achieve out of bed mobilization in the first 48-72 hours
4. Explore clinician decision making about mobilisation
This is a multi-centre cross-sectional study on one-day only. Over a 24-hour period data will be collected for all ICU patients at the participating centres (unless the patient opts out). The lead physiotherapist will record the highest level of mobility achieved that day, and the physiological parameters from clinical observations. The reasons for the level of mobility achieved will be ranked in order of importance. These data are routinely collected. Data will be pseudo-anonymised and kept securely at each the site and inputted into a Redcap Electronic Case Report Form.
Data will be analysed to determine feasibility of mobilization at 48hours and develop a flow diagram of mobilisation decision-making.
REC name
London - Queen Square Research Ethics Committee
REC reference
20/LO/0061
Date of REC Opinion
23 Apr 2020
REC opinion
Further Information Favourable Opinion