Feasibility of low energy diet in HFpEF and type 2 diabetes
Research type
Research Study
Full title
A low-energy meal replacement plan for the treatment of heart failure with preserved ejection fraction and type 2 diabetes: a feasibility study.
IRAS ID
261147
Contact name
Gerry McCann
Contact email
Sponsor organisation
University of Leicester
Duration of Study in the UK
4 years, 11 months, 31 days
Research summary
The burden of heart failure (HF) is increasing with an estimated global prevalence of 26 million people. Recent estimates suggest that almost-half a million of these patients live in the United Kingdom alone. As the prevalence of HF related morbidity and mortality increases, there is a greater need for effective preventative therapies. We will undertake a feasibility study, consisting of a twelve-week low-energy diet, to assess if a low-energy meal replacement plan (MRP) is acceptable in an older, multi-morbid, multi-ethnic population. All patients will have a cardiac MRI scan, cardiopulmonary exercise testing, body composition testing and echocardiography scan. We will assess the patients at three points: baseline, immediately following the 12-week MRP and a year-post MRP.
REC name
East Midlands - Nottingham 2 Research Ethics Committee
REC reference
19/EM/0221
Date of REC Opinion
13 Sep 2019
REC opinion
Further Information Favourable Opinion