FatigueBraIn
Research type
Research Study
Full title
Characterising fatigue phenotypes and their neural underpinnings in children and young people with Acquired Brain Injury
IRAS ID
360624
Contact name
Davinia Fernandez-Espejo
Contact email
Sponsor organisation
University of Birmingham
Duration of Study in the UK
3 years, 0 months, 0 days
Research summary
Moderate to severe acquired brain injury (ABI) is a leading cause of death and disability in children and young people in the UK, with around 35,000 emergency visits annually. Fatigue—both physical and cognitive—is a prevalent and debilitating symptom in children and young people with ABI, significantly affecting academic performance, social participation, and overall quality of life. Despite its impact, the underlying mechanisms remain unclear, and treatment options are limited. As a first step to try to develop a mechanistically informed intervention, our aim is to characterise different phenotypes of fatigue symptoms and their neural bases.
REC name
East of England - Essex Research Ethics Committee
REC reference
26/EE/0026
Date of REC Opinion
13 Feb 2026
REC opinion
Favourable Opinion