FATE-CD

• Research type

  Research Study

• Full title

  Investigating fibrosis activity and progression in Crohn’s disease (FATE CD)

• IRAS ID

  332586

• Contact name

  Rahul Kalla

• Contact email

  rahul.kalla@ed.ac.uk

• Sponsor organisation

  University of Edinburgh

• Duration of Study in the UK

  4 years, 0 months, 0 days

• Research summary

  Crohn’s Disease (CD) is a chronic inflammatory condition that can affect any part of the intestine and currently has no cure. Recent data suggests that the despite significant progress in treatments over the last 2 decades to help control
  disease, upto half of patients still develop progressive bowel scarring that require surgery and upto 70% needing surgery within a 10 years from diagnosis. Preservation of a healthy length of small bowel that is free of disease is critical to prevent the long term risk of gut failure and death. Our current treatments focus on resolving inflammation but there are no treatments targeting scarring (fibrosis), its activity and its progression. A major hurdle in our progress towards anti-scarring treatments and advancing care in Crohn's disease has been our inability to identify bowel scarring accurately; this being critical in developing new treatments that prevent permanent bowel damage. By improving our understanding of the pattern and timing of scarring, we may be able to help develop new anti-scarring drugs for this condition.

  We aim to study bowel scarring (fibrosis) in patients at different stages of their disease, firstly comparing patients due to undergo surgery (for severe scarring and bowel narrowing) to healthy controls and then finally studying how scarring evolves in Crohn's disease patients who are due to commence drug therapy.
  Patients will be approached to take part in the study and once consent has been obtained a mutually convenient time will be organised for the participant to fill in questionnaires for the study, provide blood and stool samples and undergo a PET/MRI scan

• REC name

  South East Scotland REC 01

• REC reference

  24/SS/0002

• Date of REC Opinion

  16 Feb 2024

• REC opinion

  Further Information Favourable Opinion