Fast Track Faecal Calprotectin
Research type
Research Study
Full title
Prospective Assessment of the Predictive Power of Faecal Calprotectin in Patients with Fast Track Colorectal Symptoms
IRAS ID
156515
Contact name
James Turvill
Contact email
Sponsor organisation
York Foundation Trust R & D Unit
Research summary
The aim of this study is to determine prospectively the negative and positive predictive power of faecal calprotectin for organic disease in new patients referred from primary care with fast track lower gastrointestinal symptoms. The predictive power of faecal calprotectin for patients with colorectal cancer will additionally be assessed. Should this prove to be a safe and effective test then this study would inform an NIHR application to re-model the current fast track and non fast track colorectal guidelines currently used in primary care. Currently the cancer detection rate in high risk patients is thought to be <10%. The diagnosis of organic disease amongst this cohort is likely to be considerably higher. The management of fast track referrals is nonetheless demanding on secondary care resource. If a safe effective mechanism of improving the risk stratification of symptomatic patients could be identified and actioned from the primary care level then considerable savings would accrue.
REC name
East Midlands - Leicester South Research Ethics Committee
REC reference
14/EM/0217
Date of REC Opinion
21 May 2014
REC opinion
Further Information Favourable Opinion