Failure to establish Recycling in Neonates (FeRN)
Research type
Research Study
Full title
Failure to establish recycling (mucous fistula re-feeding) in neonates.
IRAS ID
234541
Contact name
Ingo Jester
Contact email
Sponsor organisation
Birmingham Women's and Children's NHS Foundation Trust
Duration of Study in the UK
1 years, 5 months, 1 days
Research summary
Babies often need life-saving surgery, in which their bowel is stitched to the skin as two openings called ‘stoma’ and ‘mucous fistula’. After the operation, difficulties absorbing milk and poor growth can occur because nutrients in stool that pour out of the stoma are thrown away. One treatment for this takes the stoma content and refeeds it back into the other end of the bowel (mucous fistula); ‘Mucous Fistula Refeeding (MFR)’. It works by restoring the normal bowel pathway and helping nutrient absorption. However, this treatment is associated with complications such as severe infection and even death. By testing bacteria and chemicals in babies’ stool and urine, we hope to predict these complications and stop MFR before harm occurs.
Therefore, babies who have a stoma and mucous fistula who have the above mentioned difficulties will be eligible for recruitment. The study will take place within a single NHS trust across 2 sites. The study will last 12 months and the participants will provide stool and urine samples which will be tested.
REC name
East Midlands - Leicester Central Research Ethics Committee
REC reference
19/EM/0030
Date of REC Opinion
1 Jul 2019
REC opinion
Further Information Favourable Opinion