Faecal Microflora in ITP vs1

• Research type

  Research Study

• Full title

  Is Immune thrombocytopaenic purpura (ITP) associated with an abnormal faecal microflora?

• IRAS ID

  168157

• Contact name

  John Hunter

• Contact email

  john.hunter@addenbrookes.nhs.uk

• Sponsor organisation

  Cambridge University NHS Foundation Trust

• Duration of Study in the UK

  1 years, months, days

• Research summary

  SUMMARY
  The finding of an abnormal profile of toxic compounds of bacterial origin in patients with ITP has suggested that faecal antigens might lead to the production of antibodies which cross react with other tissues including platelets. Such a mechanism might be a cause of thrombocytopaenia in ITP. This study will test that hypothesis by investigating whether the abnormal metabolic profile found in the urine correlates with an abnormal faecal bacterial flora revealed by routine culture of the bacteria in faeces together with Illumina sequencing of bacterial DNA. Such evidence may lead to new methods of diagnosis, and to treatment of ITP by manipulation of the intestinal microflora.

• REC name

  East Midlands - Derby Research Ethics Committee

• REC reference

  15/EM/0023

• Date of REC Opinion

  16 Jan 2015

• REC opinion

  Further Information Favourable Opinion